Molecular Evolution and Functional Divergence of Trace Amine-Associated Receptors
Seong-il Eyun, Hideaki Moriyama, Federico G. Hoffmann, and Etsuko N. Moriyama
PLoS ONE 11: e0151023
— Figures (Colored and High resolution) —
- (pdf) Figure 1. Syntenic relationship of the TAAR genes in nine vertebrate genomes.
- (pdf) Figure 2. The maximum-likelihood phylogeny of TAAR proteins from ten representative vertebrate species.
- (pdf) Figure 3.The maximum-likelihood phylogeny of TAAR proteins from 24 gnathostome genomes.
- (pdf) Figure 4. The number of TAAR genes within each TAAR subfamily for each therian species.
- (pdf) Figure 5. The 3D-structural model of the elephant TAAR7a protein (cyan) superimposed with the turkey Beta1-adrenergic receptor (Beta1AR, gray).
- (pdf) Figure S1. The maximum-likelihood phylogeny of TAAR proteins from 25 vertebrates. - The expanded version of Figure S1 (pdf)
- (pdf) Figure S2. TAAR signature motifs from TAAR subfamilies (a), from the TAAR3 subfamily (b), and from weakly conserved fish TAARs (c).
- (pdf) Figure S3. TAAR signature motifs found in the two elephant shark (Callorhinchus milii) TAAR protein sequences.
- (pdf) Figure S4. PAML branch-model tests between primary amine-detecting TAARs (TAAR1 and TAAR3) and tertiary amine-detecting TAARs (TAAR7 and TAAR8).
- (pdf) Figure S5. Modeling of the 3D-structure of TAAR proteins.
- (pdf) Figure S6. Multiple alignment of the four TAAR and the turkey ет1-adrenergic receptor proteins.
- (pdf) Figure S7. Alignments of the positively selected sites identified in TAAR7 (a) and TAAR8 (b).
— Table —
- (pdf) Table 1. The number of TAAR genes identified in the 30 animal genomes.
- (pdf) Table S1. The animal genomes used in this study.
- (Excel file) Table S2. TAAR sequences used and identified in this study.
- (pdf) Table S3. The results of PAML site-model analysis for TAAR subfamilies.
- (pdf) Table S4. The results of PAML branch-site model analysis.
— Supplementary Data —
[Phylogenetic trees in Newick format]
Figure 2. Ten representative animals (based on MAFFT)
- maximum-likelihood tree in Newick format
- neighbor-joining tree in Newick format
- Bayesian tree in Newick format
Figure 3. 24 gnathostome genomes (based on MAFFT)
- maximum-likelihood tree in Newick format
- neighbor-joining tree in Newick format
- Bayesian tree in Newick format
[TAAR protein sequences in FASTA format]
See Supplementary Table S2 for the description of each sequence
[TAAR alignments]
[TreeSAAP results]
Amino acid substitutions are analyzed in the context of 539 physicochemical properties from the amino acid index (AAindex)
